Screening for a diamond in the rough

Chem Biol. 2013 Sep 19;20(9):1091-2. doi: 10.1016/j.chembiol.2013.09.002.

Abstract

Contrary to the standard of eliminating antimicrobial hits that collapse bacterial proton motive force (PMF), in this issue of Chemistry and Biology, Farha and colleagues describe the value of screens to identify molecules that dissipate PMF, yet are nonbacteriolytic and selectively toxic.

Publication types

  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Humans
  • Proton-Motive Force / drug effects*
  • Staphylococcus aureus / metabolism*

Substances

  • Anti-Bacterial Agents