The 51st Eastern Analytical Symposium (EAS) and Exposition was held at the Garden State Exhibit Center in Somerset NJ, USA, from 12-15 November 2012, with a theme of 'Energizing Analytical Solutions'. This conference attracted and energized a diverse group of attendees, presenters, and exhibitors, whose expertise covered the broad topics of analysis in various fields and spanned the frontiers of science through innovation and understanding of nature. The presentations relevant to bioanalysis included: characterization and quantitation of biologics/biomarkers, LC-MS bioanalysis, DBS analysis, microdosing strategy, novel sample preparation techniques, new LC stationary phases, and laboratory management. This conference report highlights some of the lectures and sessions of interest to bioanalysts at the 2012 EAS.