Abstract
Resveratrol, a natural polyphenol compound, has broad effects on critical events, including inflammation, oxidation, cancer and aging. However, the function and molecular mechanisms of resveratrol on T cell activation are controversial. In the present study, we found that resveratrol significantly inhibits the activation and cytokine production of T cells in vitro and in vivo. Sirt1 expression was up-regulated in resveratrol-treated T cells. Once Sirt1 was down-regulated in the T cells, the resveratrol-induced inhibition of T cell activation noticeably diminished. The acetylation of c-Jun decreased and its translocation was impeded in the resveratrol-treated T cells. The incidence and severity of collagen-induced arthritis in the resveratrol-treated mice were considerably reduced.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetylation / drug effects
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
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Arthritis, Experimental / chemically induced
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Arthritis, Experimental / drug therapy*
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Arthritis, Experimental / metabolism
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Blotting, Western
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CD4-Positive T-Lymphocytes / drug effects*
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CD4-Positive T-Lymphocytes / metabolism
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CD4-Positive T-Lymphocytes / pathology
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Cell Nucleus / metabolism
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Cell Proliferation / drug effects
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Collagen / toxicity
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Enzyme-Linked Immunosorbent Assay
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Gene Expression Regulation / drug effects*
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Immunoprecipitation
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JNK Mitogen-Activated Protein Kinases / metabolism
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Lymphocyte Activation / drug effects*
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Male
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Mice
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Mice, Inbred C57BL
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Mice, Inbred DBA
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Mice, Knockout
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Resveratrol
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Sirtuin 1 / metabolism*
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Stilbenes / pharmacology*
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Stilbenes
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Collagen
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JNK Mitogen-Activated Protein Kinases
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Sirt1 protein, mouse
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Sirtuin 1
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Resveratrol