Primaquine failure and cytochrome P-450 2D6 in Plasmodium vivax malaria

N Engl J Med. 2013 Oct 3;369(14):1381-2. doi: 10.1056/NEJMc1301936.
No abstract available

Publication types

  • Clinical Trial, Phase I
  • Letter
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Cytochrome P-450 CYP2D6 / deficiency
  • Cytochrome P-450 CYP2D6 / genetics*
  • Cytochrome P-450 CYP2D6 / metabolism
  • Female
  • Humans
  • Malaria, Vivax / drug therapy*
  • Male
  • Metabolism, Inborn Errors*
  • Middle Aged
  • Parasitemia / drug therapy
  • Phenotype
  • Plasmodium vivax / drug effects
  • Primaquine / metabolism
  • Primaquine / therapeutic use*
  • Recurrence
  • Treatment Failure
  • Young Adult

Substances

  • Cytochrome P-450 CYP2D6
  • Primaquine

Supplementary concepts

  • Drug Metabolism, Poor, CYP2D6-Related