Abstract
We investigated the anticonvulsant effect of acute Fuzi total alkaloid (FTA) in seizure induced by the GABAA-receptor antagonist pentylenetetrazole (PTZ). FTA significantly increased the seizure latency and decreased the mortality in PTZ-treated mice. Administration of PTZ increased c-Fos expression in the hippocampus, medial prefrontal cortex, and piriform cortex; and this PTZ-induced effect was inhibited by FTA in a dose-dependent manner. Furthermore, the effects of FTA on PTZ-induced seizure and c-Fos expression were reversed by the GABAA/benzodiazepine receptor-selective antagonist flumazenil. These findings suggest that the anticonvulsant effects of FTA may be related to modulation of GABAA-benzodiazepine receptor complex.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anticonvulsants / pharmacology*
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Cerebral Cortex / metabolism
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Disease Models, Animal
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Diterpenes
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Dose-Response Relationship, Drug
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Drugs, Chinese Herbal
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Flumazenil / pharmacology
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GABA-A Receptor Antagonists*
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Hippocampus / metabolism
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Male
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Mice
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Mice, Inbred ICR
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Pentylenetetrazole* / antagonists & inhibitors
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Phytotherapy*
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Plant Extracts / pharmacology*
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Proto-Oncogene Proteins c-fos / metabolism
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Receptors, GABA-A / metabolism*
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Seizures / chemically induced*
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Seizures / drug therapy*
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Seizures / metabolism
Substances
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Anticonvulsants
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Diterpenes
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Drugs, Chinese Herbal
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GABA-A Receptor Antagonists
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Plant Extracts
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Proto-Oncogene Proteins c-fos
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Receptors, GABA-A
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fuzi drug herbal
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Flumazenil
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Pentylenetetrazole