Invasive Aspergillus niger complex infections in a Belgian tertiary care hospital

Clin Microbiol Infect. 2014 May;20(5):O333-5. doi: 10.1111/1469-0691.12394. Epub 2013 Nov 4.

Abstract

The incidence of invasive infections caused by the Aspergillus niger species complex was 0.043 cases/10 000 patient-days in a Belgian university hospital (2005-2011). Molecular typing was performed on six available A. niger complex isolates involved in invasive disease from 2010 to 2011, revealing A. tubingensis, which has higher triazole minimal inhibitory concentrations, in five out of six cases.

Keywords: Aspergillosis; Aspergillus niger; Aspergillus niger infection; Invasive pulmonary aspergillosis; drug resistance; fungal.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Antifungal Agents / therapeutic use*
  • Aspergillosis / drug therapy
  • Aspergillosis / epidemiology*
  • Aspergillosis / microbiology*
  • Aspergillus niger / classification
  • Aspergillus niger / drug effects
  • Aspergillus niger / isolation & purification*
  • Belgium
  • Female
  • Humans
  • Incidence
  • Itraconazole / therapeutic use
  • Male
  • Microbial Sensitivity Tests
  • Middle Aged
  • Molecular Typing
  • Mycological Typing Techniques
  • Retrospective Studies
  • Tertiary Care Centers
  • Triazoles / therapeutic use
  • Voriconazole / therapeutic use

Substances

  • Antifungal Agents
  • Triazoles
  • Itraconazole
  • posaconazole
  • Voriconazole