New biologically active hydrogen sulfide donors

Thomas Roger; Francoise Raynaud; Frédéric Bouillaud; Céline Ransy; Serge Simonet; Christine Crespo; Marie-Pierre Bourguignon; Nicole Villeneuve; Jean-Paul Vilaine; Isabelle Artaud; Erwan Galardon

doi:10.1002/cbic.201300552

New biologically active hydrogen sulfide donors

Chembiochem. 2013 Nov 25;14(17):2268-71. doi: 10.1002/cbic.201300552. Epub 2013 Oct 2.

Authors

Thomas Roger¹, Francoise Raynaud, Frédéric Bouillaud, Céline Ransy, Serge Simonet, Christine Crespo, Marie-Pierre Bourguignon, Nicole Villeneuve, Jean-Paul Vilaine, Isabelle Artaud, Erwan Galardon

Affiliation

¹ UMR 8601, LCBPT, CNRS-Université Paris Descartes, PRES Sorbonne Paris Cité, 45 rue des Sts Pères, 75006 Paris (France).

PMID: 24115650
DOI: 10.1002/cbic.201300552

Abstract

Generous donors: The dithioperoxyanhydrides (CH3 COS)2 , (PhCOS)2 , CH3 COSSCO2 Me and PhCOSSCO2 Me act as thiol-activated hydrogen sulfide donors in aqueous buffer solution. The most efficient donor (CH3 COS)2 can induce a biological response in cells, and advantageously replace hydrogen sulfide in ex vivo vascular studies.

Keywords: SQR; biological activity; dithioperoxyanhydrides; hydrogen sulfide; oxidoreductases; vasorelaxation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Disulfides / chemical synthesis
Disulfides / chemistry
Disulfides / metabolism*
Hydrogen Sulfide / chemistry
Hydrogen Sulfide / metabolism*
Molecular Structure

Substances

Disulfides
Hydrogen Sulfide