Lack of association between the LPR and VNTR polymorphisms of the serotonin transporter gene and cocaine dependence in a Spanish sample

Alba Tristán-Noguero; Noèlia Fernàndez-Castillo; Carlos Roncero; Cristina Sánchez-Mora; Josep Antoni Ramos-Quiroga; Constanza Daigre; Angel Egido; Joan Alvarós; Gemma Prat; Miquel Casas; Bru Cormand; Marta Ribasés

doi:10.1016/j.psychres.2013.09.004

Lack of association between the LPR and VNTR polymorphisms of the serotonin transporter gene and cocaine dependence in a Spanish sample

Psychiatry Res. 2013 Dec 30;210(3):1287-9. doi: 10.1016/j.psychres.2013.09.004. Epub 2013 Oct 8.

Authors

Alba Tristán-Noguero¹, Noèlia Fernàndez-Castillo, Carlos Roncero, Cristina Sánchez-Mora, Josep Antoni Ramos-Quiroga, Constanza Daigre, Angel Egido, Joan Alvarós, Gemma Prat, Miquel Casas, Bru Cormand, Marta Ribasés

Affiliation

¹ Departament de Genètica, Facultat de Biologia, Universitat de Barcelona, Spain.

PMID: 24120036
DOI: 10.1016/j.psychres.2013.09.004

Abstract

We genotyped the LPR and VNTR polymorphisms of the serotonin transporter gene in 504 cocaine-dependent patients and 508 controls. No association was detected with either polymorphism or with any haplotype combination. This study provided no evidence that these polymorphisms confer susceptibility to cocaine dependence in our sample.

Keywords: 5HTT; Association study; Drug addiction.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Case-Control Studies
Cocaine-Related Disorders / ethnology*
Cocaine-Related Disorders / genetics*
Genotype
Haplotypes
Humans
Male
Minisatellite Repeats / genetics*
Polymerase Chain Reaction / methods
Polymorphism, Genetic*
Serotonin Plasma Membrane Transport Proteins / genetics*
Spain
White People / ethnology
White People / genetics

Substances

SLC6A4 protein, human
Serotonin Plasma Membrane Transport Proteins