Objective: To evaluate the effects of early goal-directed diuresis therapy on the outcomes of critical ill patients.
Methods: A total of 56 critical patients enrolled received an injection of furosemide 5-40 mg under a precondition of stable hemodynamics. They were divided into two groups:standard group [Central venous pressure (CVP) decreased below 8 mm Hg] (n = 30) and control group (if not) (n = 26) depending on the goal of CVP.And the differences of survival rate, intensive care unit (ICU) days and ventilation days after diuresis therapy were compared between two groups.
Results: The survival rate of standard group was significantly higher than that of control group (96.7% vs 84.6%, P < 0.05) while the ICU days (4.4 ± 3.6 days) and ventilation days (1.2 ± 1.1 days) after diuresis therapy of standard group were significantly shorter than that of control group (12.5 ± 11.7 and 9.8 ± 9.6 days, P < 0.05).
Conclusion: Early goal-directed diuresis therapy can improve the prognosis of critical ill patients.