Total synthesis and biological evaluation of jerantinine E

Angew Chem Int Ed Engl. 2013 Dec 9;52(50):13373-6. doi: 10.1002/anie.201305533. Epub 2013 Oct 14.
No abstract available

Keywords: alkaloids; cancer; indoles; natural products; total synthesis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents, Phytogenic / chemical synthesis
  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Aspidosperma / chemistry*
  • Cell Line
  • Cell Movement / drug effects
  • Cell Proliferation / drug effects
  • Cell Survival / drug effects
  • Dose-Response Relationship, Drug
  • Drug Screening Assays, Antitumor
  • Humans
  • Indole Alkaloids
  • MCF-7 Cells
  • Mice
  • Molecular Conformation
  • Polymerization / drug effects
  • Stereoisomerism
  • Structure-Activity Relationship
  • Tubulin / metabolism
  • Vinca Alkaloids / chemical synthesis
  • Vinca Alkaloids / chemistry
  • Vinca Alkaloids / pharmacology*

Substances

  • Antineoplastic Agents, Phytogenic
  • Indole Alkaloids
  • Tubulin
  • Vinca Alkaloids
  • jerantinine E