Keywords: Animal model; CLDN1; HCV; HCVcc; IFN; IFNAR; IRF; MAVS; OCLN; PKR; RIG-I; SR-BI; STAT; Vaccines; cell culture-derived HCV; claudin-1; hEF; hepatitis C virus; human entry factor; interferon; interferon regulatory factor; interferon-alfa receptor; mitochondrial antiviral-signaling protein; occludin; protein kinase R; retinoic acid-inducible gene I; scavenger receptor class B type I; signal transducer and activator of transcription.