Human recombinant erythropoietins (EPO) and darbepoetins are widely used for anemias associated with chronic kidney disease. Allergic reactions to erythropoetins and darbepoetins have only occasionally been reported. These skin reactions include pruritus, wheals at the injection site, orofacial anaphylaxis and anjioedema. In this article, we report an 11 year-old female who experienced generalized erithematous skin eruption and desquamation after both erythropoietin and darbepoetin treatments. We successfully used darbepoetin with the support of premedication and desensitization.