Abstract
We report, in a clinical setting, the tigecycline concentration and area under the concentration-time curve (AUC) - both in blood and in cerebrospinal fluid (CSF) - of a patient with a ventriculo-atrial shunt infection. Tigecycline weakly penetrates CSF the CSF-to-serum concentration ratio was 0.079 and CSF-to-serum AUC(0-12) ratio was 0.067.
MeSH terms
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Adult
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Anti-Bacterial Agents / administration & dosage
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Anti-Bacterial Agents / pharmacokinetics*
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Area Under Curve
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Bacterial Infections / drug therapy
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Cerebrospinal Fluid / chemistry*
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Cerebrospinal Fluid Shunts / adverse effects
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Female
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Humans
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Minocycline / administration & dosage
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Minocycline / analogs & derivatives*
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Minocycline / pharmacokinetics
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Plasma / chemistry
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Tigecycline
Substances
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Anti-Bacterial Agents
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Tigecycline
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Minocycline