Disseminated adenovirus infection in cancer patients presenting with focal pulmonary consolidation

J Clin Microbiol. 2014 Jan;52(1):350-3. doi: 10.1128/JCM.01893-13. Epub 2013 Oct 16.

Abstract

We report disseminated adenovirus (ADV) infection in four adult cancer patients presenting with focal pulmonary consolidation. In all cases, ADV was recovered from respiratory specimens and ADV viremia (>1 × 10(5) copies/ml) was determined by a quantitative PCR assay. Despite antiviral therapy, 3 (75%) patients died. ADV should be considered as a possible cause of severe pneumonia in immunosuppressed patients.

Publication types

  • Case Reports

MeSH terms

  • Adenoviridae / genetics
  • Adenoviridae / isolation & purification*
  • Adenovirus Infections, Human / diagnosis*
  • Adenovirus Infections, Human / drug therapy
  • Adenovirus Infections, Human / pathology*
  • Adult
  • Aged
  • Antiviral Agents / therapeutic use
  • DNA, Viral / genetics
  • DNA, Viral / isolation & purification
  • Fatal Outcome
  • Female
  • Humans
  • Immunocompromised Host
  • Male
  • Neoplasms / complications*
  • Pneumonia, Viral / diagnosis*
  • Pneumonia, Viral / drug therapy
  • Pneumonia, Viral / virology
  • Polymerase Chain Reaction
  • Radiography, Thoracic
  • Tomography, X-Ray Computed
  • Viremia / diagnosis*
  • Viremia / drug therapy
  • Viremia / virology

Substances

  • Antiviral Agents
  • DNA, Viral