Moderate and severe periodontitis are independent risk factors associated with low cardiorespiratory fitness in sedentary non-smoking men aged between 45 and 65 years

J Clin Periodontol. 2014 Jan;41(1):31-7. doi: 10.1111/jcpe.12183. Epub 2013 Nov 13.

Abstract

Aim: To investigate the association between periodontal disease severity and cardiorespiratory fitness (CRF) in a cross-sectional study of sedentary men.

Materials & methods: Seventy-two healthy men (45-65 years) who did not join any sport activity and had a preferentially sitting working position were recruited. Periodontal status was recorded and CRF was measured by peak oxygen uptake (VO2 peak ) during exercise testing on a cycle ergometer. Physical activity was assessed by a validated questionnaire and data were transformed to metabolic equivalent of task scores. Univariate and multivariate regression analyses were performed to investigate associations.

Results: Differences between VO2 peak levels in subjects with no or mild, moderate or severe periodontitis were statistically significant (p = 0.026). Individuals with low VO2 peak values showed high BMI scores, high concentrations of high-sensitive C-reactive protein, low levels of high-density lipoprotein-cholesterol, and used more glucocorticoids compared to individuals with high VO2 peak levels. Multivariate regression analysis showed that high age (p = 0.090), high BMI scores (p < 0.001), low levels of physical activity (p = 0.031) and moderate (p = 0.087), respectively, severe periodontitis (p = 0.033) were significantly associated with low VO2 peak levels.

Conclusions: This study demonstrated that moderate and severe periodontitis were independently associated with low levels of CRF in sedentary men aged between 45 and 65 years.

Keywords: cardiorespiratory fitness; periodontitis; physical activity; risk factor; systemic health.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age Factors
  • Aged
  • Blood Glucose / analysis
  • Blood Pressure / physiology
  • Body Mass Index
  • Body Weight
  • C-Reactive Protein / analysis
  • Cholesterol, HDL / blood
  • Cohort Studies
  • Cross-Sectional Studies
  • Ergometry / methods
  • Glucocorticoids / therapeutic use
  • Heart / physiology
  • Humans
  • Lung / physiology
  • Male
  • Middle Aged
  • Motor Activity / physiology
  • Oxygen Consumption / physiology*
  • Periodontal Index
  • Periodontitis / classification*
  • Physical Fitness*
  • Risk Factors
  • Sedentary Behavior*

Substances

  • Blood Glucose
  • Cholesterol, HDL
  • Glucocorticoids
  • C-Reactive Protein