Persistence of measles neutralizing antibody related to vaccine and natural infection acquired before HIV infection

Epidemiol Infect. 2014 Aug;142(8):1708-12. doi: 10.1017/S0950268813002628. Epub 2013 Oct 21.

Abstract

Little is known about long-lasting measles protective immunity when exposure to wild-type or vaccine measles virus precedes HIV infection. The results obtained suggest that measles immunity wanes and the lowest measles geometric mean titres (GMT) were significantly associated with measles vaccine-induced immunity in individuals that later developed HIV infection (86% prevalence, GMT 164 mIU/ml) compared to naturally induced immunity in HIV-infected adults (100% prevalence, GMT 340 mIU/ml, P = 0·0082) or non-HIV infected adults (100%, GMT 724 mIU/ml, P = 0·0001), and vaccine-induced immunity in non-HIV-infected adults (100%, GMT 347 mIU/ml, P = 0·017). The study was conducted in an area without wild-type virus circulation since 2000. The absence of virus circulating may alter the paradigm of lifelong immunity to measles virus after vaccination. As the proportion of HIV-infected individuals possessing only vaccine-induced immunity continues to grow, checking the status of measles immunity in this group is strongly recommended.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Antibodies, Neutralizing / blood*
  • Antibodies, Viral / blood*
  • Child
  • Child, Preschool
  • Female
  • HIV Infections / immunology
  • Humans
  • Infant
  • Male
  • Measles / immunology*
  • Measles Vaccine / immunology*
  • Measles virus / immunology*
  • Middle Aged
  • Time Factors
  • Young Adult

Substances

  • Antibodies, Neutralizing
  • Antibodies, Viral
  • Measles Vaccine