Highly diastereo- and enantioselective [3+2] annulation of isatin-derived Morita-Baylis-Hillman carbonates with trifluoropyruvate catalyzed by tertiary amines

Chem Commun (Camb). 2013 Dec 7;49(94):11071-3. doi: 10.1039/c3cc46490c.

Abstract

An enantioselective [3+2] annulation of Morita-Baylis-Hillman carbonates with trifluoropyruvate catalyzed by modified cinchona alkaloids was developed in good to excellent yields with excellent diastereo- and enantioselectivities.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amines / chemistry*
  • Carbonates / chemistry*
  • Catalysis
  • Isatin / chemistry*
  • Pyruvic Acid / chemistry*
  • Stereoisomerism
  • Substrate Specificity

Substances

  • Amines
  • Carbonates
  • Isatin
  • Pyruvic Acid