SPECT and 18F-FDG PET/CT imaging of multiple paragangliomas and a growth hormone-producing pituitary adenoma as phenotypes from a novel succinate dehydrogenase subunit D mutation

Clin Nucl Med. 2014 Jan;39(1):81-3. doi: 10.1097/RLU.0000000000000235.

Abstract

Mutations in the subunits B, C, D, and recently in A of the succinate dehydrogenase have been associated with the development of paragangliomas. We report the case of a 37-year-old man presented with multiple paragangliomas and a growth hormone-producing pituitary adenoma, with a novel succinate dehydrogenase subunit D mutation as the genetic analysis revealed. We present the similarities and the differences of the findings in patient imaging with either methods of SPECT (I-MIBG and In-pentetreotide) or PET/CT with F-FDG. This case revealed that F-FDG PET/CT detected more lesions and was superior compared with the other methods.

Publication types

  • Case Reports

MeSH terms

  • Adenoma / diagnosis*
  • Adenoma / enzymology
  • Adenoma / genetics
  • Adenoma / metabolism
  • Adult
  • Fluorodeoxyglucose F18*
  • Growth Hormone / biosynthesis
  • Humans
  • Male
  • Multimodal Imaging*
  • Mutation*
  • Paraganglioma / diagnosis*
  • Paraganglioma / enzymology
  • Paraganglioma / genetics
  • Paraganglioma / metabolism
  • Phenotype
  • Pituitary Neoplasms / diagnosis*
  • Pituitary Neoplasms / enzymology
  • Pituitary Neoplasms / genetics
  • Pituitary Neoplasms / metabolism
  • Positron-Emission Tomography
  • Protein Subunits / genetics
  • Succinate Dehydrogenase / genetics*
  • Tomography, Emission-Computed, Single-Photon
  • Tomography, X-Ray Computed

Substances

  • Protein Subunits
  • Fluorodeoxyglucose F18
  • Growth Hormone
  • Succinate Dehydrogenase