Abstract
A unique quintuple-modality theranostic nanoprobe (QMT) is developed with gold nanostars for surface-enhanced Raman scattering (SERS), magnetic resonance imaging (MRI), computed tomography (CT), two-photon luminescence (TPL) imaging and photothermal therapy (PTT). The synthesized gold nanostars were tagged with a SERS reporter and linked with an MRI contrast agent Gd(3+). In vitro experiments demonstrated the developed QMT nanoprobe to be a potential theranostic agent for future biomedical applications.
MeSH terms
-
Cell Line, Tumor
-
Cell Survival / drug effects
-
Gold* / therapeutic use
-
Humans
-
Luminescence
-
Luminescent Measurements / instrumentation
-
Luminescent Measurements / methods
-
Magnetic Resonance Imaging / instrumentation
-
Magnetic Resonance Imaging / methods
-
Metal Nanoparticles* / therapeutic use
-
Molecular Probe Techniques / instrumentation
-
Multimodal Imaging / instrumentation
-
Multimodal Imaging / methods*
-
Neoplasms / pathology
-
Neoplasms / therapy
-
Phototherapy / instrumentation
-
Phototherapy / methods*
-
Prognosis
-
Spectrum Analysis, Raman / instrumentation
-
Spectrum Analysis, Raman / methods
-
Surface Plasmon Resonance / instrumentation
-
Surface Plasmon Resonance / methods
-
Tomography, X-Ray Computed / instrumentation
-
Tomography, X-Ray Computed / methods