Regulating angiogenesis with light-inducible AntimiRs

Florian Schäfer; Jasmin Wagner; Andrea Knau; Stefanie Dimmeler; Alexander Heckel

doi:10.1002/anie.201307502

Regulating angiogenesis with light-inducible AntimiRs

Angew Chem Int Ed Engl. 2013 Dec 16;52(51):13558-61. doi: 10.1002/anie.201307502. Epub 2013 Oct 31.

Authors

Florian Schäfer¹, Jasmin Wagner, Andrea Knau, Stefanie Dimmeler, Alexander Heckel

Affiliation

¹ Institute for Organic Chemistry and Chemical Biology, Buchmann Institute for Molecular Life Sciences, Goethe-University Frankfurt, Max-von-Laue-Strasse 9, 60438 Frankfurt (Germany).

PMID: 24174377
DOI: 10.1002/anie.201307502

Abstract

The inhibition of microRNAs (miRs) in a spatiotemporally defined manner by an exogenous trigger would help to specifically target the biological activity and avoid off-target effects. Novel antimiRs directed against miR-92a can be activated by irradiation (see scheme; 3'-UTR=3'-untranslated region) In this way miR-92a is inhibited, the miR-92a target integrin α5 is derepressed, and angiogenesis of endothelial cells is enhanced.

Keywords: RNA; angiogenesis; antimiR; photolysis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cells, Cultured
Humans
MicroRNAs / genetics*
Neovascularization, Pathologic
Photolysis

Substances

MicroRNAs