Abstract
Cystic fibrosis gastrointestinal disease includes nutrient malabsorption and intestinal inflammation. We show that the abundances of Escherichia coli in fecal microbiota were significantly higher in young children with cystic fibrosis than in controls and correlated with fecal measures of nutrient malabsorption and inflammation, suggesting that E. coli could contribute to cystic fibrosis gastrointestinal dysfunction.
Keywords:
Escherichia coli; cystic fibrosis; inflammation; malabsorption; microbiota.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Adolescent
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Adult
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Aged
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Aged, 80 and over
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Child
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Child, Preschool
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Cystic Fibrosis / complications*
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Dysbiosis / complications*
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Dysbiosis / microbiology*
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Escherichia coli Infections / complications*
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Escherichia coli Infections / microbiology*
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Feces / microbiology
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Female
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Gastrointestinal Diseases / etiology
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Gastrointestinal Diseases / microbiology*
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Gastrointestinal Diseases / pathology*
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Humans
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Infant
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Infant, Newborn
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Male
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Middle Aged
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Young Adult