Clean and efficient synthesis of isoxazole derivatives in aqueous media

Guolan Dou; Pan Xu; Qiang Li; Yukun Xi; Zhibin Huang; Daqing Shi

doi:10.3390/molecules181113645

Clean and efficient synthesis of isoxazole derivatives in aqueous media

Molecules. 2013 Nov 5;18(11):13645-53. doi: 10.3390/molecules181113645.

Authors

Guolan Dou¹, Pan Xu, Qiang Li, Yukun Xi, Zhibin Huang, Daqing Shi

Affiliation

¹ School of Safety Engineering, China University of Mining & Technology, Xuzhou 221116, China. [email protected].

Abstract

A series of 5-arylisoxazole derivatives were synthesized via the reaction of 3-(dimethyl-amino)-1-arylprop-2-en-1-ones with hydroxylamine hydrochloride in aqueous media without using any catalyst. This method has the advantages of easier work-up, mild reaction conditions, high yields, and an environmentally benign procedure.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Hydroxylamine / chemistry
Isoxazoles / chemistry*
Molecular Structure
Water

Substances

Isoxazoles
Water
Hydroxylamine