Regulation of activity of transcription factor NF-κB by synthetic oligonucleotides

V G Metelev; E A Kubareva; T S Oretskaya

doi:10.1134/S0006297913080026

Regulation of activity of transcription factor NF-κB by synthetic oligonucleotides

Biochemistry (Mosc). 2013 Aug;78(8):867-78. doi: 10.1134/S0006297913080026.

Authors

V G Metelev¹, E A Kubareva, T S Oretskaya

Affiliation

¹ Faculty of Chemistry, Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Leninsky Gory 1, Moscow, 119991, Russia. [email protected].

PMID: 24228874
DOI: 10.1134/S0006297913080026

Abstract

Eukaryotic dimeric nuclear factor-κB (NF-κB) is one of the main transcription factors that activate expression of genes, products of which play the key role in development of cardiovascular pathologies, carcinogenesis, and inflammatory and viral diseases. In this review, the main attention is given to modulation of the transcription factor NF-κB activity by antisense oligonucleotides and oligonucleotide decoys. Also, current concepts about interactions between NF-κB dimers and DNA and general problems that arise in experimental use of synthetic oligonucleotides in vivo are discussed.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Gene Expression Regulation
Humans
Mice
NF-kappa B / antagonists & inhibitors
NF-kappa B / genetics
NF-kappa B / metabolism*
Oligonucleotides / chemistry
Oligonucleotides / pharmacology*
Oligonucleotides, Antisense / chemistry
Oligonucleotides, Antisense / pharmacology
Protein Multimerization
Protein Subunits / antagonists & inhibitors
Protein Subunits / genetics
Protein Subunits / metabolism
RNA, Messenger / genetics

Substances

NF-kappa B
Oligonucleotides
Oligonucleotides, Antisense
Protein Subunits
RNA, Messenger