Hematologic manifestations of systemic disease (including iron deficiency, anemia of inflammation and DIC)

Char M Witmer

doi:10.1016/j.pcl.2013.08.012

Hematologic manifestations of systemic disease (including iron deficiency, anemia of inflammation and DIC)

Pediatr Clin North Am. 2013 Dec;60(6):1337-48. doi: 10.1016/j.pcl.2013.08.012. Epub 2013 Oct 4.

Author

Char M Witmer¹

Affiliation

¹ Division of Hematology, Department of Pediatrics, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, 3501 Civic Center Boulevard, CTRB 11th Floor, Room 11-026, Philadelphia, PA 19104, USA. Electronic address: [email protected].

PMID: 24237974
DOI: 10.1016/j.pcl.2013.08.012

Abstract

A complete blood cell count (CBC) is a frequent test sent to aid in the diagnostic evaluation of ill patients. Not uncommonly hematologic abnormalities may be the first sign of an underlying systemic disorder. The astute clinician needs to understand how systemic disease can affect the CBC to direct further diagnostic investigations. This article focuses on the 2 most common acquired anemias including iron deficiency and anemia of inflammation as well as disseminated intravascular coagulation.

Keywords: Anemia of inflammation; Disseminated intravascular coagulation; Function of hemoglobin; Iron deficiency anemia.

Publication types

Review

MeSH terms

Anemia / diagnosis*
Anemia / drug therapy
Anemia, Iron-Deficiency / blood
Anemia, Iron-Deficiency / diagnosis*
Anemia, Iron-Deficiency / drug therapy
Blood Cell Count
Disseminated Intravascular Coagulation / diagnosis*
Disseminated Intravascular Coagulation / drug therapy
Humans
Inflammation