Rapidly metastasizing malignant melanoma characterized by a rare BRAF mutation not responding to vemurafenib

MeSH terms

• Aged
• Antineoplastic Agents / therapeutic use
• Drug Resistance, Neoplasm
• Fatal Outcome
• Genetic Predisposition to Disease / genetics
• Humans
• Indoles / therapeutic use*
• Lung Neoplasms / diagnosis
• Lung Neoplasms / drug therapy
• Lung Neoplasms / secondary
• Male
• Melanoma / diagnosis
• Melanoma / drug therapy*
• Melanoma / genetics
• Melanoma / secondary*
• Mutation / genetics
• Polymorphism, Single Nucleotide / genetics
• Proto-Oncogene Proteins B-raf / genetics*
• Skin Neoplasms / diagnosis
• Skin Neoplasms / drug therapy*
• Skin Neoplasms / genetics*
• Sulfonamides / therapeutic use*
• Thoracic Neoplasms / diagnosis
• Thoracic Neoplasms / drug therapy
• Thoracic Neoplasms / secondary
• Treatment Failure
• Vemurafenib