Sporothrix schenckii lymphadentitis in a male with X-linked chronic granulomatous disease

Jessica R Trotter; Panida Sriaroon; David Berman; Aleksandra Petrovic; Jennifer W Leiding

doi:10.1007/s10875-013-9968-0

Sporothrix schenckii lymphadentitis in a male with X-linked chronic granulomatous disease

J Clin Immunol. 2014 Jan;34(1):49-52. doi: 10.1007/s10875-013-9968-0. Epub 2013 Nov 16.

Authors

Jessica R Trotter¹, Panida Sriaroon, David Berman, Aleksandra Petrovic, Jennifer W Leiding

Affiliation

¹ Department of Pediatrics, Division of Allergy, Immunology and Rheumatology, Children's Research Institute, University of South Florida, 140-7th Avenue South, Box 7890, St. Petersburg, FL, 33701, USA.

PMID: 24241583
DOI: 10.1007/s10875-013-9968-0

Abstract

Sporothrix schenckii lymphadenitis was identified in a 33 month old male with X-linked chronic granulomatous disease (CGD). S. schenckii is a dimorphic catalase producing fungus found in the soil of temperate and tropical climates. Host defense against S. schenckii relies primarily on innate and cellular responses and gp91(phox-/-) mice are susceptible to disseminated infection. This case represents the first report of susceptibility to sporotrichosis in a patient with CGD.

Publication types

Case Reports

MeSH terms

Antifungal Agents / therapeutic use
Biopsy
Child, Preschool
Granulomatous Disease, Chronic / complications*
Granulomatous Disease, Chronic / diagnosis
Granulomatous Disease, Chronic / therapy
Hematopoietic Stem Cell Transplantation
Humans
Lymph Nodes / pathology
Lymphadenitis / complications*
Lymphadenitis / diagnosis
Lymphadenitis / drug therapy
Lymphadenitis / microbiology*
Lymphadenitis / surgery
Male
Neck / pathology
Sporothrix*
Sporotrichosis / complications*
Sporotrichosis / diagnosis
Sporotrichosis / drug therapy

Substances

Antifungal Agents