Abstract
We compared in vitro killing of colistin, doripenem, and sulbactam by time-kill methods against Acinetobacter baumannii isolates collected from patients before and after colistin-doripenem treatment (initial and recurrent isolates, respectively). Colistin-doripenem bactericidal activity against recurrent isolates was attenuated (mean log10 kill, -5.74 versus -2.88; P = 0.01) but was restored by adding sulbactam. Doripenem MICs rather than colistin MICs correlated with the activity of colistin-doripenem. Among colistin-resistant isolates, colistin-doripenem-sulbactam combinations achieved greater killing than colistin-doripenem alone (-5.65 versus -2.43; P = 0.04).
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Acinetobacter Infections / drug therapy*
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Acinetobacter Infections / microbiology
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Acinetobacter baumannii / drug effects*
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Acinetobacter baumannii / genetics
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Acinetobacter baumannii / growth & development
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Acinetobacter baumannii / isolation & purification
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Anti-Bacterial Agents / pharmacology*
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Carbapenems / pharmacology*
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Colistin / pharmacology*
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Doripenem
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Drug Administration Schedule
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Drug Combinations
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Drug Resistance, Bacterial / genetics
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Electrophoresis, Gel, Pulsed-Field
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Humans
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Sulbactam / pharmacology*
Substances
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Anti-Bacterial Agents
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Carbapenems
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Drug Combinations
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Doripenem
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Sulbactam
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Colistin