Ultrasound-triggered regulation of blood glucose levels using injectable nano-network

Adv Healthc Mater. 2014 Jun;3(6):811-6. doi: 10.1002/adhm.201300490. Epub 2013 Nov 19.

Abstract

The integration of an injectable insulin-encapsulated nano-network with a focused ultrasound system (FUS) can remotely regulate insulin release both in vitro and in vivo. A single subcutaneous injection of the nano-network with intermittent FUS administration facilitates reduction of the blood glucose levels in type 1 diabetic mice for up to 10 d.

Keywords: diabetes; drug delivery; insulin delivery; nano-network; ultrasound.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alginates / chemistry
  • Animals
  • Blood Glucose / analysis*
  • Chitosan / chemistry
  • Diabetes Mellitus, Experimental / metabolism
  • Diabetes Mellitus, Experimental / pathology
  • Diabetes Mellitus, Experimental / therapy
  • Drug Carriers / chemistry
  • Glucuronic Acid / chemistry
  • Hexuronic Acids / chemistry
  • Hypoglycemic Agents / administration & dosage
  • Hypoglycemic Agents / chemistry
  • Insulin / administration & dosage
  • Insulin / chemistry
  • Lactic Acid / chemistry
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Nanostructures / chemistry*
  • Polyglycolic Acid / chemistry
  • Polylactic Acid-Polyglycolic Acid Copolymer
  • Ultrasonic Therapy

Substances

  • Alginates
  • Blood Glucose
  • Drug Carriers
  • Hexuronic Acids
  • Hypoglycemic Agents
  • Insulin
  • Polylactic Acid-Polyglycolic Acid Copolymer
  • Polyglycolic Acid
  • Lactic Acid
  • Glucuronic Acid
  • Chitosan