Disseminated cutaneous herpes simplex infection in a patient with Crohn's disease under azathioprine and steroids: First case report and literature review

J Crohns Colitis. 2014 Apr;8(4):326-30. doi: 10.1016/j.crohns.2013.10.011. Epub 2013 Nov 17.

Abstract

Immunosuppressive treatments used in the management of Inflammatory Bowel Disease, namely steroids, thiopurines and anti-TNF drugs, raise the risk of acquiring opportunistic infections. However, most of these infections are mild and self-limited, not requiring specific therapy or suspension of the immunosuppressors. We report a case of disseminated cutaneous herpes simplex infection in a patient with Crohn's disease under steroids and azathioprine.

Keywords: Crohn's disease; Herpes Simplex Virus; Immunosuppression.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adrenal Cortex Hormones / administration & dosage
  • Adrenal Cortex Hormones / adverse effects*
  • Adrenal Cortex Hormones / therapeutic use
  • Azathioprine / adverse effects*
  • Azathioprine / therapeutic use
  • Crohn Disease / complications
  • Crohn Disease / drug therapy*
  • Drug Therapy, Combination
  • Female
  • Herpes Simplex / chemically induced*
  • Herpes Simplex / etiology
  • Humans
  • Immunosuppressive Agents / administration & dosage
  • Immunosuppressive Agents / adverse effects*
  • Immunosuppressive Agents / therapeutic use
  • Prednisolone / administration & dosage
  • Prednisolone / adverse effects
  • Prednisolone / therapeutic use
  • Young Adult

Substances

  • Adrenal Cortex Hormones
  • Immunosuppressive Agents
  • Prednisolone
  • Azathioprine