Abstract
Despite the growing use of poxvirus vectors as vaccine candidates for multiple pathogens and cancers, their innate stimulatory properties remain poorly characterized. Here we show that the canarypox virus-based vector ALVAC induced distinct systemic proinflammatory and antiviral cytokine and chemokine levels following the vaccination of rhesus monkeys compared to the vaccinia virus-based vectors MVA and NYVAC. These data suggest that there are substantial biological differences among leading poxvirus vaccine vectors that may influence resultant adaptive immune responses following vaccination.
Publication types
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Comparative Study
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Animals
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Canarypox virus / genetics
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Canarypox virus / immunology*
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Cytokines / immunology*
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Genetic Vectors / genetics
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Genetic Vectors / immunology*
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HIV Infections / immunology
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HIV Infections / virology
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HIV-1 / immunology
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HIV-1 / physiology
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Humans
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Macaca mulatta
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Retroviridae Proteins / administration & dosage
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Retroviridae Proteins / genetics
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Retroviridae Proteins / immunology
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Simian Acquired Immunodeficiency Syndrome / immunology
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Simian Acquired Immunodeficiency Syndrome / virology
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Simian Immunodeficiency Virus / genetics
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Simian Immunodeficiency Virus / immunology
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Simian Immunodeficiency Virus / physiology
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Vaccinia virus / genetics
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Vaccinia virus / immunology*
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Viral Vaccines / administration & dosage
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Viral Vaccines / genetics
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Viral Vaccines / immunology*
Substances
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Cytokines
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Retroviridae Proteins
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Viral Vaccines