Abstract
Several transgenic mouse models have been developed which facilitate the transmission of chronic wasting disease (CWD) of cervids and allow prion strain discrimination. The present study was designed to assess the susceptibility of the prototypic mouse line, Tg(CerPrP)1536(+/-), to bovine spongiform encephalopathy (BSE) prions, which have the ability to overcome species barriers. Tg(CerPrP)1536(+/-) mice challenged with red deer-adapted BSE resulted in 90% to 100% attack rates, and BSE from cattle failed to transmit, indicating agent adaptation in the deer.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cattle
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Central Nervous System / metabolism
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Central Nervous System / pathology
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Deer / metabolism*
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Disease Models, Animal*
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Disease Susceptibility
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Encephalopathy, Bovine Spongiform / metabolism*
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Encephalopathy, Bovine Spongiform / pathology
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Encephalopathy, Bovine Spongiform / transmission
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Female
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Male
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Mice*
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Mice, Transgenic
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Prions / metabolism*
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Species Specificity
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Wasting Disease, Chronic / metabolism*
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Wasting Disease, Chronic / pathology
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Wasting Disease, Chronic / transmission