Real-world costs of chronic lymphocytic leukaemia in the Netherlands

K M Holtzer-Goor; C A M Bouwmans-Frijters; M R Schaafsma; O de Weerdt; P Joosten; E F M Posthuma; S Wittebol; P C Huijgens; E J M Mattijssen; G Vreugdenhil; H Visser; W G Peters; Z Erjavec; P W Wijermans; S M G J Daenen; K G van der Hem; M H J van Oers; C A Uyl-de Groot

doi:10.1016/j.leukres.2013.10.029

Real-world costs of chronic lymphocytic leukaemia in the Netherlands

Leuk Res. 2014 Jan;38(1):84-90. doi: 10.1016/j.leukres.2013.10.029. Epub 2013 Nov 8.

Authors

K M Holtzer-Goor¹, C A M Bouwmans-Frijters², M R Schaafsma³, O de Weerdt⁴, P Joosten⁵, E F M Posthuma⁶, S Wittebol⁷, P C Huijgens⁸, E J M Mattijssen⁹, G Vreugdenhil¹⁰, H Visser¹¹, W G Peters¹², Z Erjavec¹³, P W Wijermans¹⁴, S M G J Daenen¹⁵, K G van der Hem¹⁶, M H J van Oers¹⁷, C A Uyl-de Groot²

Affiliations

¹ Department of Health Policy & Management/Institute for Medical Technology Assessment, Erasmus University Rotterdam, Rotterdam, The Netherlands. Electronic address: [email protected].
² Department of Health Policy & Management/Institute for Medical Technology Assessment, Erasmus University Rotterdam, Rotterdam, The Netherlands.
³ Department of Haematology, Medisch Spectrum Twente, Enschede, The Netherlands.
⁴ Department of Haematology, St. Antonius Hospital Nieuwegein, Nieuwegein, The Netherlands.
⁵ Department of Haematology, Medisch Centrum Leeuwarden, Leeuwarden, The Netherlands.
⁶ Department of Haematology, Leiden University Medical Center, Leiden, The Netherlands; Department of Haematology, Reinier de Graaf Hospital, Delft, The Netherlands.
⁷ Department of Haematology, Meander Medical Center, Amersfoort, The Netherlands.
⁸ Department of Haematology, VU University Medical Center, Amsterdam, The Netherlands.
⁹ Department of Haematology, Rijnstate Hospital, Arnhem, The Netherlands.
¹⁰ Department of Haematology, Máxima Medical Center, Veldhoven, The Netherlands.
¹¹ Department of Haematology, Medical Center Alkmaar, Alkmaar, The Netherlands.
¹² Department of Haematology, Catharina Ziekenhuis Eindhoven, Eindhoven, The Netherlands.
¹³ Department of Haematology, OZG Delfzicht Ziekenhuis, Delfzijl, The Netherlands.
¹⁴ Department of Haematology, Haga Hospital, Den Haag, The Netherlands.
¹⁵ Department of Haematology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
¹⁶ Department of Haematology, Zaans Medisch Centrum, Zaandam, The Netherlands.
¹⁷ Department of Haematology, Academic Medical Center, Amsterdam, The Netherlands.

PMID: 24268350
DOI: 10.1016/j.leukres.2013.10.029

Abstract

We performed a comprehensive cost calculation identifying the main cost drivers of treatment of chronic lymphocytic leukaemia in daily practice. In our observational study 160 patient charts were reviewed repeatedly to assess the treatment strategies from diagnosis till the study end. Ninety-seven patients (61%) received ≥1 treatment lines during an average follow-up time of 6.4 years. The average total costs per patient were €41,417 (€539 per month). The costs varied considerably between treatment groups and between treatment lines. Although patients were treated with expensive chemo(immuno-)therapy, the main cost driver was inpatient days for other reasons than administration of chemo(immuno-)therapy.

Keywords: Chronic lymphocytic leukaemia; Cost of illness; Costs; Observational study; Outcomes research; Real-world.

Publication types

Observational Study
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Aged, 80 and over
Cost-Benefit Analysis
Costs and Cost Analysis
Diagnostic Tests, Routine / economics*
Diagnostic Tests, Routine / methods
Drug Therapy / economics*
Drug Therapy / methods
Female
Humans
Leukemia, Lymphocytic, Chronic, B-Cell / diagnosis*
Leukemia, Lymphocytic, Chronic, B-Cell / therapy*
Male
Middle Aged
Netherlands
Stem Cell Transplantation / economics*
Stem Cell Transplantation / methods