CTRP3 plays an important role in the development of collagen-induced arthritis in mice

Biochem Biophys Res Commun. 2014 Jan 3;443(1):42-8. doi: 10.1016/j.bbrc.2013.11.040. Epub 2013 Nov 20.

Abstract

Rheumatoid arthritis (RA) is an autoimmune inflammatory disease exhibited most commonly in joints. We found that the expression of C1qtnf3, which encodes C1q/TNF-related protein 3 (CTRP3), was highly increased in two mouse RA models with different etiology. To elucidate the pathogenic roles of CTRP3 in the development of arthritis, we generated C1qtnf3(-/-) mice and examined the development of collagen-induced arthritis in these mice. We found that the incidence and severity score was higher in C1qtnf3(-/-) mice compared with wild-type (WT) mice. Histopathology of the joints was also more severe in C1qtnf3(-/-) mice. The levels of antibodies against type II collagen and pro-inflammatory cytokine mRNAs in C1qtnf3(-/-) mice were higher than WT mice. These observations indicate that CTRP3 plays an important role in the development of autoimmune arthritis, suggesting CTRP3 as a possible medicine to treat RA.

Keywords: CTRP3; Collagen-induced arthritis; Rheumatoid arthritis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adipokines / genetics
  • Adipokines / physiology*
  • Amino Acid Sequence
  • Animals
  • Arthritis, Experimental / genetics*
  • Arthritis, Experimental / pathology
  • Arthritis, Rheumatoid / genetics*
  • Arthritis, Rheumatoid / pathology
  • Autoimmunity
  • B-Lymphocytes / immunology
  • Collagen Type II / immunology
  • Humans
  • Joints / immunology
  • Joints / pathology
  • Mice
  • Mice, Inbred C57BL
  • Molecular Sequence Data

Substances

  • Adipokines
  • CORS26 protein, mouse
  • Collagen Type II