Absence of an important vaccine and diagnostic target in carriage- and disease-related nontypeable Haemophilus influenzae

Heidi C Smith-Vaughan; Anne B Chang; Derek S Sarovich; Robyn L Marsh; Keith Grimwood; Amanda J Leach; Peter S Morris; Erin P Price

doi:10.1128/CVI.00632-13

Absence of an important vaccine and diagnostic target in carriage- and disease-related nontypeable Haemophilus influenzae

Clin Vaccine Immunol. 2014 Feb;21(2):250-2. doi: 10.1128/CVI.00632-13. Epub 2013 Nov 27.

Authors

Heidi C Smith-Vaughan¹, Anne B Chang, Derek S Sarovich, Robyn L Marsh, Keith Grimwood, Amanda J Leach, Peter S Morris, Erin P Price

Affiliation

¹ Menzies School of Health Research, Charles Darwin University, Darwin, Australia.

Abstract

Nontypeable Haemophilus influenzae (NTHi)-associated disease is a major health problem globally. Whole-genome sequence analysis identified the absence of hpd genes encoding Haemophilus protein D in 3 of 16 phylogenetically distinct NTHi isolates. This novel finding is of potential clinical significance, as protein D and hpd represent important NTHi vaccine antigen and diagnostic targets, respectively.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antigens, Bacterial / genetics*
Carrier State / diagnosis
Carrier State / epidemiology
Carrier State / microbiology
Carrier State / prevention & control*
Child
Child, Preschool
Cluster Analysis
DNA, Bacterial / genetics
Female
Gene Deletion*
Genes, Bacterial
Global Health
Haemophilus Infections / diagnosis
Haemophilus Infections / epidemiology
Haemophilus Infections / microbiology
Haemophilus Infections / prevention & control*
Haemophilus Vaccines / immunology*
Haemophilus Vaccines / isolation & purification
Haemophilus influenzae / classification
Haemophilus influenzae / genetics
Haemophilus influenzae / immunology*
Haemophilus influenzae / isolation & purification
Humans
Infant
Male
Phylogeny

Substances

Antigens, Bacterial
DNA, Bacterial
Haemophilus Vaccines