Abstract
The reaction of Auoxo6, a dinuclear gold(III) complex, with the model protein bovine pancreatic ribonuclease is explored here by X-ray diffraction and ESI mass spectrometry. Data provide clues on the processes of adduct formation and of enzyme inhibition and, inductively, on the likely mode of action of this metallodrug.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Auranofin / chemistry
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Auranofin / toxicity
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Cattle
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Cell Death / drug effects
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Crystallography, X-Ray
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Gold / chemistry
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Gold / metabolism*
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Gold / toxicity*
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Hydrolysis / drug effects
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Models, Molecular
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Ribonuclease, Pancreatic / chemistry*
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Ribonuclease, Pancreatic / metabolism*
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Saccharomyces cerevisiae / drug effects
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Saccharomyces cerevisiae / enzymology
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Spectrometry, Mass, Electrospray Ionization
Substances
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Auranofin
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Gold
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Ribonuclease, Pancreatic