1 From the Department of Anaesthesia and Intensive Care, Evangelical Hospital Vienna, Vienna, Austria (SAKL), Copenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark (GI), Department of Anaesthesiology and Critical Care Medicine, Franziskus Hospital Bielefeld, Bielefeld, Germany (NRM), Department of Anaesthesia, Mother and Children's Section, Juliane Marie Center, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark and Department of Pediatric and Neonatal Intensive Care Service, Geneva University Hospital, Geneva, Switzerland (AA).