Abstract
Twenty-seven patients with disseminated malignant melanoma were treated with combination chemotherapy consisting of bleomycin, actinomycin D, DTIC and vindesine. There were 4 complete responses in patients with pulmonary metastasis, 5 patients had a partial remission, 2 of them had mainly lung lesions. Toxicity consisted mainly of leuco- and thrombocytopenia of short duration and sporadic severe mucositis.
MeSH terms
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Adult
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
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Bleomycin / administration & dosage
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Dacarbazine / administration & dosage
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Dactinomycin / administration & dosage
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Drug Evaluation
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Female
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Humans
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Lung Neoplasms / drug therapy
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Lung Neoplasms / secondary
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Male
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Melanoma / drug therapy*
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Middle Aged
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Vindesine / administration & dosage
Substances
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Bleomycin
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Dactinomycin
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Dacarbazine
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Vindesine