Commentary in support of a highly effective hypertension treatment algorithm

J Clin Hypertens (Greenwich). 2013 Dec;15(12):874-7. doi: 10.1111/jch.12182. Epub 2013 Aug 7.

Abstract

A simple hypertension treatment algorithm has contributed to the achievement of control rates greater than 85% for more than 1 million adults with hypertension across the United States. It is built on the fixed-dose combination drug lisinopril/hydrochlorothiazide, which is maximized in three steps before adding amlodipine. Spironolactone is the preferred fourth drug.

MeSH terms

  • Adult
  • Algorithms
  • Amlodipine / therapeutic use*
  • Antihypertensive Agents / therapeutic use*
  • Blood Pressure / drug effects*
  • Drug Combinations
  • Drug Therapy, Combination
  • Humans
  • Hydrochlorothiazide / therapeutic use*
  • Hypertension / drug therapy*
  • Lisinopril / therapeutic use*
  • Spironolactone / therapeutic use*
  • Treatment Outcome
  • United States

Substances

  • Antihypertensive Agents
  • Drug Combinations
  • hydrochlorothiazide, lisinopril drug combination
  • Hydrochlorothiazide
  • Amlodipine
  • Spironolactone
  • Lisinopril