Abstract
The expression of CD100 semaphorin by the intact peripheral blood T lymphocytes in multiple sclerosis (MS) has been studied. The level of middle florescence intensity (MFI) and the number of B-lymphocytes bearing CD72 were evaluated. There were significant differences in the level of CD100 in patients compared to healthy volunteers. These data suggest the use of semaphorin as a possible therapeutic target in pathological inflammation in MS.
Publication types
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Comparative Study
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English Abstract
MeSH terms
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Adult
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Antigens, CD / biosynthesis*
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Antigens, CD / immunology
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Antigens, Differentiation, B-Lymphocyte / immunology
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Female
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Humans
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Immunity, Cellular*
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Lymphocyte Activation
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Male
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Middle Aged
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Multiple Sclerosis, Relapsing-Remitting / blood
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Multiple Sclerosis, Relapsing-Remitting / immunology*
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Semaphorins / biosynthesis*
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Semaphorins / immunology
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T-Lymphocytes / immunology*
Substances
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Antigens, CD
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Antigens, Differentiation, B-Lymphocyte
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CD100 antigen
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CD72 protein, human
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Semaphorins