[Allergic encephalomyelitis in guinea pigs on the intracutaneous and subcutaneous administration of fragment 114-122 of the human myelin cationic protein]

A G Ishchenko; N Ia Kovanova; N A Gorina; S N Maksimov; T I Belova

[Allergic encephalomyelitis in guinea pigs on the intracutaneous and subcutaneous administration of fragment 114-122 of the human myelin cationic protein]

Biull Eksp Biol Med. 1987 Jan;103(1):92-4.

[Article in Russian]

Authors

A G Ishchenko, N Ia Kovanova, N A Gorina, S N Maksimov, T I Belova

PMID: 2432968

Abstract

Single intracutaneous injection of 30 micrograms of human basic myelin protein peptide 114-122 (H-Phe-Ser-Trp-Gly-Ala-Glu-Gly-Gln-Arg-OH) with Freund adjuvant induced the onset of encephalomyelitis on day 9-19 after the injection. The lethality was 33%. In autumn the disease was more severe than in summer.

Publication types

Comparative Study
English Abstract

MeSH terms

Animals
Disease Models, Animal
Dose-Response Relationship, Drug
Encephalomyelitis, Autoimmune, Experimental / chemically induced*
Encephalomyelitis, Autoimmune, Experimental / mortality
Freund's Adjuvant / administration & dosage
Guinea Pigs
Humans
Injections, Intradermal
Injections, Subcutaneous
Male
Myelin Basic Protein / administration & dosage*
Peptide Fragments / administration & dosage*
Seasons
Time Factors

Substances

Myelin Basic Protein
Peptide Fragments
myelin basic protein 114-122
Freund's Adjuvant