TERT promoter mutation and aberrant hypermethylation are associated with elevated expression in medulloblastoma and characterise the majority of non-infant SHH subgroup tumours

Acta Neuropathol. 2014 Feb;127(2):307-9. doi: 10.1007/s00401-013-1225-3. Epub 2013 Dec 12.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Cerebellar Neoplasms / classification
  • Cerebellar Neoplasms / genetics
  • Cerebellar Neoplasms / metabolism*
  • Child
  • Child, Preschool
  • Cohort Studies
  • DNA Methylation / genetics*
  • DNA, Neoplasm / genetics
  • Epigenomics
  • Gene Expression Regulation, Neoplastic / genetics
  • Humans
  • Medulloblastoma / classification
  • Medulloblastoma / genetics
  • Medulloblastoma / metabolism*
  • Mutation / genetics*
  • Promoter Regions, Genetic / genetics*
  • Telomerase / genetics*
  • Telomerase / metabolism*

Substances

  • DNA, Neoplasm
  • TERT protein, human
  • Telomerase