Abstract
Thirty-three patients with advanced, metastatic APUD tumors (islet cell, carcinoid, or medullary carcinomas of the thyroid) were treated with etoposide as a single agent. Of 29 evaluable patients, four (14%) had partial responses (95% confidence limits, 1%-26%). Toxic effects seen were those previously reported for etoposide as a single agent. Etoposide has activity in APUD tumors; further studies with this agent are indicated.
MeSH terms
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Adenoma, Islet Cell / drug therapy*
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Adult
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Aged
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Calcitonin / blood
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Carcinoembryonic Antigen / analysis
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Carcinoid Tumor / drug therapy*
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Drug Evaluation
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Etoposide / adverse effects
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Etoposide / therapeutic use*
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Female
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Gastrins / blood
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Humans
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Hydroxyindoleacetic Acid / blood
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Male
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Middle Aged
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Thyroid Neoplasms / drug therapy*
Substances
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Carcinoembryonic Antigen
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Gastrins
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Hydroxyindoleacetic Acid
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Etoposide
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Calcitonin