High mitochondrial accumulation of new gadolinium(III) agents within tumour cells

Daniel E Morrison; Jade B Aitken; Martin D de Jonge; Joseph A Ioppolo; Hugh H Harris; Louis M Rendina

doi:10.1039/c3cc46903d

High mitochondrial accumulation of new gadolinium(III) agents within tumour cells

Chem Commun (Camb). 2014 Mar 4;50(18):2252-4. doi: 10.1039/c3cc46903d. Epub 2013 Dec 19.

Authors

Daniel E Morrison¹, Jade B Aitken, Martin D de Jonge, Joseph A Ioppolo, Hugh H Harris, Louis M Rendina

Affiliation

¹ School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia. [email protected].

PMID: 24352097
DOI: 10.1039/c3cc46903d

Abstract

The first bifunctional Gd(III) complexes covalently bound to arylphosphonium cations and the first tumour-cell selective mitochondrial agents designed for potential application in binary cancer therapies are reported. The highest in vitro cellular uptake for any Gd complex reported to date is described, with levels exceeding 10(10) Gd atoms per tumour cell.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemistry
Antineoplastic Agents / metabolism
Antineoplastic Agents / pharmacology*
Cell Line, Tumor
Dose-Response Relationship, Drug
Drug Design
Drug Screening Assays, Antitumor
Gadolinium / chemistry
Gadolinium / metabolism
Gadolinium / pharmacology*
Humans
Mitochondria / chemistry
Mitochondria / drug effects*
Mitochondria / metabolism
Molecular Structure
Neoplasms / drug therapy*
Neoplasms / metabolism
Neoplasms / pathology
Organometallic Compounds / chemistry
Organometallic Compounds / metabolism
Organometallic Compounds / pharmacology*
Structure-Activity Relationship

Substances

Antineoplastic Agents
Organometallic Compounds
Gadolinium