Abstract
Helicobacter pylori (H. pylori) is a major etiological factor in the development of gastric cancer. Large-scale epidemiological studies have confirmed the strong association between H. pylori infection and both cancer development and progression. Interleukin-8 (IL-8) is overexpressed in gastric mucosa exposed to H. pylori. The expression of IL-8 directly correlates with a poor prognosis in gastric cancer. IL-8 is multifunctional. In addition to its potent chemotactic activity, it can induce proliferation and migration of cancer cells. In this review, we focus on recent insights into the mechanisms of IL-8 signaling associated with gastric cancer. The relationship between IL-8 and H. pylori is discussed. We also summarize the current therapeutics against IL-8 in gastric cancer.
Keywords:
Gastric cancer; Helicobacter pylori; Interleukin-8; Signals; Therapeutics.
© 2013 Baishideng Publishing Group Co., Limited. All rights reserved.
MeSH terms
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Animals
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / therapeutic use
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Cell Transformation, Neoplastic / chemically induced
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Cell Transformation, Neoplastic / immunology
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Cell Transformation, Neoplastic / metabolism
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Drug Design
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Gastric Mucosa / immunology
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Gastric Mucosa / metabolism*
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Gastric Mucosa / microbiology*
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Helicobacter Infections / epidemiology
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Helicobacter Infections / immunology
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Helicobacter Infections / metabolism*
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Helicobacter Infections / microbiology*
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Helicobacter pylori / immunology
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Helicobacter pylori / pathogenicity*
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Humans
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Interleukin-8 / antagonists & inhibitors
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Interleukin-8 / metabolism*
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Molecular Targeted Therapy
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Prognosis
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Receptors, Interleukin-8 / antagonists & inhibitors
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Receptors, Interleukin-8 / metabolism
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Risk Factors
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Signal Transduction
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Stomach Neoplasms / immunology
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Stomach Neoplasms / metabolism*
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Stomach Neoplasms / microbiology*
Substances
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Antineoplastic Agents
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CXCL8 protein, human
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Interleukin-8
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Receptors, Interleukin-8