Systematic investigations of different cytosine modifications on CpG dinucleotide sequences: the effects on the B-Z transition

Shaoru Wang; Yuelin Long; Jiaqi Wang; Yushu Ge; Pu Guo; Yi Liu; Tian Tian; Xiang Zhou

doi:10.1021/ja4107012

Systematic investigations of different cytosine modifications on CpG dinucleotide sequences: the effects on the B-Z transition

J Am Chem Soc. 2014 Jan 8;136(1):56-9. doi: 10.1021/ja4107012. Epub 2013 Dec 27.

Authors

Shaoru Wang¹, Yuelin Long, Jiaqi Wang, Yushu Ge, Pu Guo, Yi Liu, Tian Tian, Xiang Zhou

Affiliation

¹ College of Chemistry and Molecular Sciences, Key Laboratory of Biomedical Polymers of Ministry of Education, Wuhan University , Wuhan, Hubei 430072, P. R. China.

PMID: 24364741
DOI: 10.1021/ja4107012

Abstract

We have first demonstrated the distinctive effects of three newly reported epigenetic modifications, including 5hmC, 5fC, and 5caC, on B-Z transition of CpG dinucleotide DNAs. We have performed detailed assays and compared their effects. We further studied the regulation of B-Z transition of CpG dinucleotide dodecamers by alternating oxidation and alternating reduction.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Circular Dichroism
Cytosine / chemistry*
DNA / chemistry*
Dinucleoside Phosphates / chemistry*
Epigenomics
Humans
Molecular Structure
Oxidation-Reduction

Substances

Dinucleoside Phosphates
cytidylyl-3'-5'-guanosine
Cytosine
DNA