Application of single-vial ready-for-use formulation of 111In- or 177Lu-labelled somatostatin analogs

Appl Radiat Isot. 2014 Feb:85:28-33. doi: 10.1016/j.apradiso.2013.10.023. Epub 2013 Dec 10.

Abstract

For the sake of safety it would be desirable to store and transport the ready-for-use liquid formulation (diagnostics and therapeutics) of radiolabelled peptides. The use of ethanol, in combination with a mixture of gentisic- and ascorbic acid, has superior effects on stabilizing radiolabelled somatostatin analogs. As a consequence, (111)In- and (177)Lu-labelled somatostatin analogs can be stored and transported in a single-vial ready-for-use liquid formulation up to 7 days after radiolabelling.

Keywords: Ascorbic acid; Ethanol; Gentisic acid; Quenchers; Radiochemical purity; Somatostatin.

MeSH terms

  • Ascorbic Acid
  • Chemistry, Pharmaceutical
  • Chromatography, High Pressure Liquid
  • Drug Stability
  • Drug Storage
  • Ethanol
  • Gentisates
  • Humans
  • Indium Radioisotopes / administration & dosage*
  • Indium Radioisotopes / therapeutic use
  • Lutetium / administration & dosage*
  • Lutetium / therapeutic use
  • Radioisotopes / administration & dosage*
  • Radioisotopes / therapeutic use
  • Radiopharmaceuticals / administration & dosage*
  • Radiopharmaceuticals / therapeutic use
  • Solutions
  • Somatostatin / analogs & derivatives*
  • Somatostatin / therapeutic use

Substances

  • Gentisates
  • Indium Radioisotopes
  • Radioisotopes
  • Radiopharmaceuticals
  • Solutions
  • Ethanol
  • Somatostatin
  • Lutetium
  • Ascorbic Acid
  • 2,5-dihydroxybenzoic acid