Abstract
Thirty-three Salmonella enterica serovar Typhi blood isolates from Lima, Peru (2008 to 2012), were fully susceptible to trimethoprim-sulfamethoxazole, chloramphenicol, ceftriaxone, and tetracycline; 8/33 (24.2%) showed intermediate susceptibility to ciprofloxacin carrying mutations in the quinolone resistance-determining region of the gyrA gene (Ser83-Phe and Asp87-Asn) and in the gyrB gene (Ser464-Phe).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Animals
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Anti-Bacterial Agents / pharmacology*
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Blood / microbiology
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Child
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Child, Preschool
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Ciprofloxacin / pharmacology*
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DNA Gyrase / genetics
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Drug Resistance, Bacterial*
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Female
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Genotype
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Humans
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Male
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Microbial Sensitivity Tests
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Mutation, Missense
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Peru
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Salmonella typhi / drug effects*
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Salmonella typhi / isolation & purification
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Typhoid Fever / microbiology*
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Young Adult
Substances
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Anti-Bacterial Agents
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Ciprofloxacin
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DNA Gyrase