Abstract
We conducted a case-control study to examine associations between parasite infection, including protozoa infection, and tuberculosis (TB) in children in Lima, Peru. We enrolled 189 matched-pairs. In multivariable conditional logistic regression analyses, Blastocystis hominis infection (rate ratio = 0.30, 95% confidence interval = 0.14-0.64, P = 0.002) was strongly associated with a lower risk of TB. We observed a statistically significant inverse linear dose-response relationship between Blastocystis hominis infection and TB. These findings should be confirmed in future prospective studies.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amebiasis / complications
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Amebiasis / epidemiology*
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Blastocystis Infections / complications
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Blastocystis Infections / epidemiology*
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Blastocystis hominis / isolation & purification
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Case-Control Studies
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Child
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Child, Preschool
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Endolimax / isolation & purification
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Entamoeba / isolation & purification
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Entamoebiasis / complications
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Entamoebiasis / epidemiology*
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Female
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Giardia lamblia / isolation & purification
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Giardiasis / complications
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Giardiasis / epidemiology*
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Humans
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Logistic Models
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Male
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Multivariate Analysis
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Peru
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Protozoan Infections / complications
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Protozoan Infections / epidemiology*
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Risk Factors
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Tuberculosis / complications
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Tuberculosis / epidemiology*
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Tuberculosis / parasitology