Abstract
Enteroviruses (EV) have been increasingly identified as the causative agent for unknown etiological encephalitis in many parts of the world, but the long period surveillance for enterovirus-associated encephalitis (EAE) was not reported in China. From 2002-2012 in Zhejiang, Coxsackieviruses A9, B1, B2, B3, B4, B5; and echoviruses 3, 4, 6, 9, 14, 25, 30 were detected from the unknown etiological encephalitis cases, with coxsackievirus B4 been identified here for the first time. From 2002-2004 and 2010-2012, echovirus 30 was found to be the periodically predominant serotype for in the EAE. The molecular typing results showed that all the EV isolates from this study belonged to the human EV B (HEV B) family and were distributed in three clusters.
Publication types
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Clinical Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Child
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Child, Preschool
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China / epidemiology
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Encephalitis, Viral* / epidemiology
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Encephalitis, Viral* / genetics
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Encephalitis, Viral* / virology
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Enterovirus* / isolation & purification
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Female
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Humans
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Infant
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Male
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Retrospective Studies
Grants and funding
This work was supported by grants from Science and Technology department of Zhejiang, China (2012C33063), Zhejiang Provincial Program for the Cultivation of High-Level Innovative Health Talents and Monitor Technology Platform of Infectious Diseases of the State Major Science and Technology Special Projects during the 12th five-year plan of China (2012ZX10004-210). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.