Abstract We report the case of a 73-year-old woman who suffered from amyloidosis secondary to rheumatoid arthritis (RA) complicated with Graves' ophthalmopathy. She had goiter, diplopia, and exophthalmos with polyarthralgia. We diagnosed Graves' ophthalmopathy with thyroid-stimulating hormone (TSH)-receptor antibodies (TBII and TSAb). The amyloid deposit was detected in her stomach. The complication of Graves' ophthalmopathy in amyloidosis secondary to RA has rarely been reported.